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Some Countries Authorize Ivermectin to Treat Covid-19 Against WHO Advice

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The ivermectin, an anti-parasitic medicine, is sometimes used to treat Covid-19 despite medical recommendations against it. But countries react differently.

On April 7, a South African court issued an order allowing doctors to prescribe medicines that contain ivermectin to be used for the treatment of Covid-19. The judgment states that the South African Health Products Regulatory Authority “is enabling the use of ivermectin for the purpose of treating or preventing Covid-19“.

The decision follows a legal action taken by South African healthcare practitioners, a civil right organization, the African Christian Democratic Party or pharmaceutical wholesalers in order to provide access to the medicine.

Some would like ivermectin to be authorized for covid-19 treatment

Ivermectin is used to treat skin conditions like rosacea or scabies and diseases caused by parasites or worms like the ascaris. This compound is on the World Health Organization’s list of essential medicines.

However, not all countries approve ivermectin for human use, but the active agent can usually be administered to animals and cattle.

In South Africa, ivermectin was only authorized for animal treatment, and for humans in rare occasions.

But international attention grew on the ivermectin as a treatment of Covid-19 in the past months, especially in Latin America and in Asia.

The ivermectin can treat this adult ascaris
A worm like the ascaris can be treated with an anti-parasitic: the ivermectin

In April 2021, the Philippines authorities insisted that people who would sell ivermectin to humans may face fines or even up to 10 years of imprisonment after that a local pharmaceutical firm applied for a certificate product registration,

South Africa also noticed a widespread unregulated use of ivermectin, either for veterinary purpose or sourced from illegal importation.

According to the BBC, the price of the pills soared 15-fold on the South African black market, despite several major drug regulation agencies advising not to use the active agent outside of the usual authorizations.

Several medical agencies ask not to use ivermectin to treat Covid-19

About 50 studies have been conducted on the ivermectin efficacy around the world so far.

Even Merck declared in February 2021 there was “no meaningful evidence for efficacy in patients with Covid-19 disease“. The manufacturer of Stromectol, a medicine approved for human use in the U.S. that includes ivermectin, even highlighted “a concerning lack of safety data in the majority of studies“.

WHO has now updated its guidelines of Covid-19 treatments. It considers that “the current evidence on the use of ivermectin to treat Covid-19 patients is inconclusive. Until more data is available, WHO recommends that the drug only be used within clinical trials.

Coronavirus
The WHO advises not to use ivermectin to treat covid-19

The U.S. Food and Drug Administration warned that some doses can be “highly toxic in humans“, pointing out that the ivermectin given to animals like horses or cows should not be used to humans.

They include ivermectin in much greater quantity, along with inactive ingredients with unknown effects when absorbed by humans.

Czechia and Slovakia approved the use of ivermectin against covid-19

The European Medicine Agency also released a statement on March 22, 2021 in which it advised “against use of ivermectin for the prevention or treatment of COVID-19 outside randomised clinical trials“.

It also noted that in vitro results blocking replication of SARS-CoV-2 were achieved with much higher doses than authorised. Moreover, some studies showed no benefit and others only reported a potential benefit.

As a consequence, the French regulation agency, the Agence Nationale du M├ędicament, declined a request for a temporary use of ivermectim.

But despite EMA recommendations, Slovakia and Czechia, two European Union members, allowed the temporary use of the ivermectin for Covid-19 treatment within the remit of their national legislation.

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